ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

Base Information

Chemical Name:ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate
CAS No.:1420069-12-0
Molecular Formula:C₂₆H₂₇F₃N₂O₃
Molecular Weight:472.507
Hs Code.:

Synonyms:ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

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Chemical Property of ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

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Technology Process of ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

There total 8 articles about ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1420069-14-2
N-ethyl-N-[2-(1H-indol-3-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

: 105-36-2
ethyl bromoacetate

: 1420069-12-0
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

Guidance literature:: N-ethyl-N-[2-(1H-indol-3-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.25h; Cooling with ice;

ethyl bromoacetate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 1219936-26-1
N-ethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

: 1344340-83-5
ethyl 2-(3-bromo-1H-indol-1-yl)acetate

: 1420069-12-0
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; at 85 ℃; for 2h;

Reference yield:

: 120-72-9
indole

: 1420069-12-0
ethyl {3-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-indol-1-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; potassium iodide / acetonitrile / 20 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C

3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 2 h / 85 °C

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; caesium carbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;