dimethyl 4-{2-[(methoxycarbonyl)amino]-1H-benzimidazol-6-yl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:dimethyl 4-{2-[(methoxycarbonyl)amino]-1H-benzimidazol-6-yl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:121497-18-5
Molecular Formula:C₂₀H₂₂N₄O₆
Molecular Weight:414.418
Hs Code.:
Mol file:121497-18-5.mol

Synonyms:3,5-Pyridinedicarboxylicacid,1,4-dihydro-4-[2-[(methoxycarbonyl)amino]-1H-benzimidazol-5-yl]-2,6-dimethyl-,dimethyl ester (9CI)

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Chemical Property of dimethyl 4-{2-[(methoxycarbonyl)amino]-1H-benzimidazol-6-yl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.356g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of dimethyl 4-{2-[(methoxycarbonyl)amino]-1H-benzimidazol-6-yl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 4 articles about dimethyl 4-{2-[(methoxycarbonyl)amino]-1H-benzimidazol-6-yl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 34840-23-8
1,3-bis-(methoxycarbonyl)-S-methylisothiourea

: 121497-15-2
4-(3,4-diaminophenyl)-2,6-dimethyl-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine

: 121497-18-5
4-(2-Methoxycarbonylamino-1H-benzoimidazol-5-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 4h; Heating;
DOI:10.1021/jm00130a012

Reference yield:

: 51818-99-6
4-amino-3-nitro-benzaldehyde

: 121497-18-5
4-(2-Methoxycarbonylamino-1H-benzoimidazol-5-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / ethane-1,2-diol / 24 h / Heating

2: 72 percent / H₂ / Raney Ni / methanol / 2 h / 1838.8 Torr

3: 70 percent / p-TsOH / methanol / 4 h / Heating

With hydrogen; toluene-4-sulfonic acid; nickel; In methanol; ethylene glycol;
DOI:10.1021/jm00130a012

Reference yield:

: 121497-08-3
4-(4-Amino-3-nitro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

: 121497-18-5
4-(2-Methoxycarbonylamino-1H-benzoimidazol-5-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / H₂ / Raney Ni / methanol / 2 h / 1838.8 Torr

2: 70 percent / p-TsOH / methanol / 4 h / Heating

With hydrogen; toluene-4-sulfonic acid; nickel; In methanol;
DOI:10.1021/jm00130a012