tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate
CAS No.:1380092-28-3
Molecular Formula:C₂₃H₃₈N₂O₈
Molecular Weight:470.563
Hs Code.:

Synonyms:tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Suppliers and Price of tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

There total 5 articles about tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1380092-15-8
tert-butyl 2-hydroxy-3,5,6-trimethoxybenzylcarbamate

: 13734-40-2
(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid

: 1380092-28-3
tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: tert-butyl 2-hydroxy-3,5,6-trimethoxybenzylcarbamate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.tet.2012.04.024

Reference yield:

: 30225-87-7
2,4,5-trimethoxyphenyl formate

: 1380092-28-3
tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 2 h

2.1: trifluoroacetic acid / 20 h / Inert atmosphere; Reflux

2.2: 2 h / Reflux

3.1: tert-butyldimethylsilane; trifluoroacetic acid / acetonitrile / 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

4.2: 0 - 20 °C

With tert-butyldimethylsilane; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; acetonitrile; 2.1: Duff reaction / 2.2: Duff reaction;
DOI:10.1016/j.tet.2012.04.024

Reference yield:

: 4460-86-0,14374-62-0
asaraldehyde

: 1380092-28-3
tert-butyl (2S,3R)-3-tert-butoxy-1-(2-hydroxy-3,5,6-trimethoxybenzylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: potassium hydroxide / ethanol / 2 h

3.1: trifluoroacetic acid / 20 h / Inert atmosphere; Reflux

3.2: 2 h / Reflux

4.1: tert-butyldimethylsilane; trifluoroacetic acid / acetonitrile / 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C

5.2: 0 - 20 °C

With tert-butyldimethylsilane; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; acetonitrile; 1.1: Baeyer-Villiger oxidation / 3.1: Duff reaction / 3.2: Duff reaction;
DOI:10.1016/j.tet.2012.04.024