dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

Base Information

Chemical Name:dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate
CAS No.:1309975-96-9
Molecular Formula:C₃₂H₂₆Cl₂N₂O₈
Molecular Weight:637.473
Hs Code.:

Synonyms:dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

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Chemical Property of dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

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Technology Process of dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

There total 4 articles about dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1309975-93-6
(E)-5-[4-acetylamino-3-(methoxycarbonyl)-styryl]-1-[2-(3,4-dichlorophenyl)-2-oxoethyl]-2-methylpyridinium bromide

: 762-42-5
dimethyl acetylenedicarboxylate

: 1309975-96-9
dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1.16667h;
DOI:10.1134/S1070428011040191

Reference yield:

: methyl (E)-2-(acetylamino)-5-[2-(6-methylpyridin-3-yl)ethenyl]benzoate

: 1309975-96-9
dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 48 h / 20 °C

2: triethylamine / dichloromethane / 1.17 h / 20 °C

With triethylamine; In diethyl ether; dichloromethane;
DOI:10.1134/S1070428011040191

Reference yield:

: 140-76-1,25038-86-2
2-methyl-5-vinylpyridine

: 1309975-96-9
dimethyl (E)-8-[4-acetylamino-3-(methoxycarbonyl)styryl]-3-(3,4-dichlorobenzoyl)-5-methylindolizine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

2: diethyl ether / 48 h / 20 °C

3: triethylamine / dichloromethane / 1.17 h / 20 °C

With triethylamine; In diethyl ether; dichloromethane; 1: Heck reaction;
DOI:10.1134/S1070428011040191