2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide
CAS No.:1378427-30-5
Molecular Formula:C₂₂H₂₄BFN₂O₆S
Molecular Weight:474.318
Hs Code.:

Synonyms:2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

There total 8 articles about 2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₄₂BFN₂O₇S

: 1378427-30-5
2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 66h; under 3000.3 Torr;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1378427-30-5
2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 25 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4: potassium hydroxide; water / ethanol / 0.5 h / Reflux

5: triethylamine; HATU / N,N-dimethyl-formamide / 12 h / Inert atmosphere

6: potassium carbonate / acetonitrile / Reflux

7: bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

8: hydrogen / palladium on activated charcoal / ethyl acetate / 66 h / 3000.3 Torr

With potassium fluoride; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium bromide; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid ethyl ester

: 1378427-30-5
2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N,5-dimethyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide; water / ethanol / 0.5 h / Reflux

2: triethylamine; HATU / N,N-dimethyl-formamide / 12 h / Inert atmosphere

3: potassium carbonate / acetonitrile / Reflux

4: bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

5: hydrogen / palladium on activated charcoal / ethyl acetate / 66 h / 3000.3 Torr

With water; hydrogen; potassium carbonate; triethylamine; HATU; potassium hydroxide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;