2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Base Information

Chemical Name:2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid
CAS No.:1378428-88-6
Molecular Formula:C₁₇H₁₄FNO₅S
Molecular Weight:363.366
Hs Code.:

Synonyms:2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

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Chemical Property of 2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

There total 3 articles about 2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid ethyl ester

: 1378428-88-6
2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Guidance literature:: 2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid ethyl ester; With water; potassium hydroxide; In ethanol; for 0.5h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1378428-88-6
2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 25 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4: potassium hydroxide; water / ethanol / 0.5 h / Reflux

With potassium fluoride; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium bromide; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 1378428-85-3
ethyl 2-(4-fluorophenyl)-5-methyl-6-nitro-1-benzofuran-3-carboxylate

: 1378428-88-6
2-(4-fluorophenyl)-5-methyl-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: potassium hydroxide; water / ethanol / 0.5 h / Reflux

With water; hydrogen; N-ethyl-N,N-diisopropylamine; potassium hydroxide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;