N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

Base Information

Chemical Name:N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide
CAS No.:1089210-29-6
Molecular Formula:C₂₃H₂₈Cl₂N₂O₄S
Molecular Weight:499.458
Hs Code.:

Synonyms:N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

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Chemical Property of N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

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Technology Process of N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

There total 5 articles about N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.1%

: 1089210-15-0
2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofuran-5-sulfonic acid N-[4-(3-chloro-phenyl)-piperazin-1-yl]-amide

: 109-70-6
1.3-chlorobromopropane

: 1089210-29-6
N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 3h;

Reference yield:

: 1089210-09-2
7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonyl chloride

: 1089210-29-6
N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / 0 - 5 °C

2: methanol; water; sodium carbonate / 28 h / 20 °C

3: potassium hydroxide / ethanol / 3 h / 20 °C

With methanol; potassium hydroxide; water; sodium carbonate; In ethanol;

Reference yield:

: 1089210-08-1
7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonic acid

: 1089210-29-6
N-[4-(3-chloro-phenyl)-piperazin-1-yl]-2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentachloride / 2 h / -5 - 34 °C / Cooling with acetone-dry ice

2: ethanol / 2 h / 0 - 5 °C

3: methanol; water; sodium carbonate / 28 h / 20 °C

4: potassium hydroxide / ethanol / 3 h / 20 °C

With methanol; potassium hydroxide; phosphorus pentachloride; water; sodium carbonate; In ethanol;