(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

Base Information

Chemical Name:(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester
CAS No.:1027567-06-1
Molecular Formula:C₂₇H₃₅N₃O₆
Molecular Weight:497.591
Hs Code.:

Synonyms:(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

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Chemical Property of (S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

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Technology Process of (S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

There total 1 articles about (S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 35264-09-6
1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: (S)-2-Amino-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

: 1027567-06-1
(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm960323z

Reference yield:

: 1027567-06-1
(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

: (S)-2-[(1-Amino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; for 0.25h;
DOI:10.1021/jm960323z

Reference yield:

: 1027567-06-1
(S)-2-[(1-tert-Butoxycarbonylamino-cyclopentanecarbonyl)-amino]-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

: (S)-2-{[1-((S)-2-Acetylsulfanyl-3-methyl-butyrylamino)-cyclopentanecarbonyl]-amino}-3-(4-methoxy-phenyl)-propionic acid pyridin-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / CH₂Cl₂ / 0.25 h

2: Et₃N, 1,3-dicyclohexylcarbodiimide, 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 16 h

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm960323z