1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

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Chemical Name:1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione
CAS No.:910040-51-6
Molecular Formula:C₄₉H₅₂N₂O₅Si₂
Molecular Weight:805.133
Hs Code.:

1-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1<i>H</i>-pyrimidine-2,4-dione

Synonyms:1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 906794-95-4
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-iodo-1H-pyrimidine-2,4-dione

: 1066-54-2
trimethylsilylacetylene

: 910040-51-6
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

Guidance literature:: With TEA; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-200060046

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 910040-51-6
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide

2: 79 percent / TEA / (Ph₃P)4Pd; CuI / dimethylformamide

With 1H-imidazole; TEA; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1081/NCN-200060046

Reference yield:

: 15414-61-6
2'-deoxy-5-iodo-5'-O-(triphenylmethyl)uridine

: 910040-51-6
1-[4-(tert-butyl-diphenyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-5-trimethylsilanylethynyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide

2: 79 percent / TEA / (Ph₃P)4Pd; CuI / dimethylformamide

With 1H-imidazole; TEA; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1081/NCN-200060046