2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

Base Information

Chemical Name:2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid
CAS No.:1447364-11-5
Molecular Formula:C₁₈H₁₇ClFN₃O₄
Molecular Weight:393.802
Hs Code.:

Synonyms:2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

Suppliers and Price of 2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

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Chemical Property of 2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

Chemical Property:

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Technology Process of 2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

There total 4 articles about 2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 511230-95-8
1-(5-fluoro-2-methylphenyl)piperazine

: 114776-15-7
2-chloro-4-fluoro-5-nitrobenzoic acid

: 1447364-11-5
2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 1422-53-3
2-bromo-4-fluorotoluene

: 1447364-11-5
2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane / 20 - 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; caesium carbonate; trifluoroacetic acid; XPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1121599-96-9
4-(5-fluoro-2-methylphenyl)piperazine-1-carboxylic acid tert-butyl ester

: 1447364-11-5
2-chloro-4-[4-(5-fluoro-2-methylphenyl)piperazin-1-yl]-5-nitrobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;