Technology Process of Benzoic acid (1R,9S,10R)-5-methoxy-3-oxo-9-(tetrahydro-furan-2-yloxy)-11-oxa-2,4-diaza-tricyclo[7.2.1.02,7]dodeca-4,6-dien-10-ylmethyl ester
There total 14 articles about Benzoic acid (1R,9S,10R)-5-methoxy-3-oxo-9-(tetrahydro-furan-2-yloxy)-11-oxa-2,4-diaza-tricyclo[7.2.1.02,7]dodeca-4,6-dien-10-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
toluene;
at 110 ℃;
for 1.5h;
DOI:10.1248/cpb.36.162
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) n-BuLi / 1.) THF/n-hexane, -35 deg C, 1 h, 2.) THF, -35 deg C, 1 h
2: tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / Ambient temperature
3: pyridine / Ambient temperature
4: 90 percent trifluoroacetic acid / 1.5 h / Ambient temperature
5: Et3N / CH2Cl2 / 2 h
6: 82 percent / stannic chloride / acetonitrile / 3 h / Ambient temperature
7: 82 percent / p-toluenesulfonic acid / dioxane / Ambient temperature
8: 80 percent / MeOH, Et3N / 3 h / Ambient temperature
9: 72 percent / dimethylformamide / Ambient temperature
10: 43 percent / Bu3SnH, AIBN / toluene / 1.5 h / 110 °C
With
pyridine; methanol; n-butyllithium; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; tin(IV) chloride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1248/cpb.36.162
- Guidance literature:
-
Multi-step reaction with 8 steps
1: pyridine / Ambient temperature
2: 90 percent trifluoroacetic acid / 1.5 h / Ambient temperature
3: Et3N / CH2Cl2 / 2 h
4: 82 percent / stannic chloride / acetonitrile / 3 h / Ambient temperature
5: 82 percent / p-toluenesulfonic acid / dioxane / Ambient temperature
6: 80 percent / MeOH, Et3N / 3 h / Ambient temperature
7: 72 percent / dimethylformamide / Ambient temperature
8: 43 percent / Bu3SnH, AIBN / toluene / 1.5 h / 110 °C
With
pyridine; methanol; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tin(IV) chloride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1248/cpb.36.162
