(1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate

Base Information

• Chemical Name: (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate
• CAS No.: 1374035-63-8
• Molecular Formula: C₂₄H₂₀ClFN₂O₅S
• Molecular Weight: 502.951

Synonyms:(1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate

Chemical Property of (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate

There total 4 articles about (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N1-(4-chloro-3-fluorophenyl)-N2-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide (1226788-48-2) + p-toluenesulfonyl chloride (98-59-9) → (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate (1374035-63-8)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm300265j

Reference yield:

ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate (1226789-23-6) → (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate (1374035-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / 150 °C / sealed tube

2: dmap; triethylamine / tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere

With dmap; triethylamine; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm300265j

Reference yield:

(1S,2R)-1-amino-2-indanol (7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8) → (1S,2R)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl 4-methylbenzenesulfonate (1374035-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / 150 °C / sealed tube

2: dmap; triethylamine / tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere

With dmap; triethylamine; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm300265j

upstream raw materials:

ethyl 2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetate

N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide

p-toluenesulfonyl chloride

(1S,2R)-1-amino-2-indanol

Downstream raw materials:

N¹-((1S,2S)-2-azido-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)oxalamide

amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

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