amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

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Chemical Name:amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate
CAS No.:1374035-59-2
Molecular Formula:CH₂O₂*C₁₈H₁₇ClFN₅O₂
Molecular Weight:435.842
Hs Code.:

Synonyms:

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Chemical Property of amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

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Technology Process of amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

There total 7 articles about amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 64-18-6
formic acid

: 1374035-62-7
N¹-((1S,2S)-2-amino-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)oxalamide

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1374035-59-2
amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

Guidance literature:: N¹-((1S,2S)-2-amino-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)oxalamide; 1H-pyrazole-1-carboximidamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Inert atmosphere;

formic acid; lyophilization;
DOI:10.1021/jm300265j

Reference yield:

: 1374035-57-0
N¹-((1S,2S)-2-azido-2,3-dihydro-1H-inden-1-yl)-N²-(4-chloro-3-fluorophenyl)oxalamide

: 1374035-59-2
amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Pb-poisoned 5% Pd-CaCO3; hydrogen / methanol / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

2.2: lyophilization

With Pb-poisoned 5% Pd-CaCO3; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm300265j

Reference yield:

: 1226788-48-2
N¹-(4-chloro-3-fluorophenyl)-N²-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)oxalamide

: 1374035-59-2
amino(((1S,2S)-1-(2-((4-chloro-3-fluorophenyl)amino)-2-oxoacetamido)-2,3-dihydro-1H-inden-2-yl)amino)methaniminium formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 2.5 h / 50 °C / Inert atmosphere

3.1: Pb-poisoned 5% Pd-CaCO3; hydrogen / methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

4.2: lyophilization

With dmap; sodium azide; Pb-poisoned 5% Pd-CaCO3; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300265j