2-nitrobenzo[de]chromene

Base Information

• Chemical Name: 2-nitrobenzo[de]chromene
• CAS No.: 105052-38-8
• Molecular Formula: C₁₂H₇NO₃
• Molecular Weight: 213.192
• Mol file: 105052-38-8.mol

Synonyms:R 7780

Chemical Property of 2-nitrobenzo[de]chromene

Chemical Property:

• Vapor Pressure: 2.09E-05mmHg at 25°C
• Boiling Point: 372.2°Cat760mmHg
• Flash Point: 182.3°C
• PSA: 55.05000
• Density: 1.42g/cm³
• LogP: 3.33050

Purity/Quality:

99% ^*data from raw suppliers

R 7780 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-nitrobenzo[de]chromene

There total 3 articles about 2-nitrobenzo[de]chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-methoxynaphthalene-1-carbaldehyde (35689-27-1) → nitro-2 naphto<1,8-bc>pyranne (105052-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

2: 1) K₂CO₃, 2) Ac₂O / 1) acetone, 0 deg C, 4 h then RT, overnight, 2) reflux, 1 h

With aluminium trichloride; acetic anhydride; potassium carbonate; In dichloromethane;

Reference yield:

1-Methoxynaphthalene (2216-69-5) → nitro-2 naphto<1,8-bc>pyranne (105052-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) t-BuLi / 1) hexane, cyclohexane, 10 h RT, 2) hexane, cyclohexane, ether, 60 deg C, 6 h

2: 81 percent / AlCl₃ / CH₂Cl₂ / 48 h / Ambient temperature

3: 1) K₂CO₃, 2) Ac₂O / 1) acetone, 0 deg C, 4 h then RT, overnight, 2) reflux, 1 h

With aluminium trichloride; tert.-butyl lithium; acetic anhydride; potassium carbonate; In dichloromethane;

Reference yield:

bromonitromethane (563-70-2) + 1-hydroxynaphthalene-8-carboxaldehyde (35689-26-0) → nitro-2 naphto<1,8-bc>pyranne (105052-38-8)

Guidance literature:

With acetic anhydride; potassium carbonate; Yield given. Multistep reaction; 1) acetone, 0 deg C, 4 h then RT, overnight, 2) reflux, 1 h;

upstream raw materials:

bromonitromethane

1-hydroxynaphthalene-8-carboxaldehyde

8-methoxynaphthalene-1-carbaldehyde

1-Methoxynaphthalene

Refernces

• 1、 Royer,Buisson,Vleminckx,Moens. "About new highly genotoxic agents: Oxaphenalene nitro derivatives". . p. 351 - 354. Retrieved 2007/10/02.