5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide

Base Information

Chemical Name:5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide
CAS No.:101565-18-8
Molecular Formula:C21H25 N3 O2
Molecular Weight:351.4421
Hs Code.:
DSSTox Substance ID:DTXSID40906370
Nikkaji Number:J227.587B
ChEMBL ID:CHEMBL7585
Mol file:101565-18-8.mol

Synonyms:1H-Indole-7-carboxamide, 5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-;5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide;AY 28925;AY-28925

Suppliers and Price of 5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide

Chemical Property:

Vapor Pressure:5.82E-17mmHg at 25°C
Boiling Point:634.3°Cat760mmHg
Flash Point:337.4°C
Density:1.222g/cm³
XLogP3:2.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:351.19467705
Heavy Atom Count:26
Complexity:453

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCC1=CC=CC=C1)NCC(C2=CC(=C3C(=C2)C=CN3)C(=O)N)O

Technology Process of 5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide

There total 12 articles about 5-(1-Hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-1H-indole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16078-30-1
1-Acetyl-2,3-dihydro-1H-indole

: 101565-18-8
5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)amino>ethyl>-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) aluminum chloride / 1.) 1,2-dichloroethane, 20 min, 2.) 1,2-dichloroethane, 50 deg C, 1 h

2: dimethylformamide / 2 h / 60 °C

3: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

4: 94.5 percent / pyridine / Ambient temperature

5: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

6: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

7: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

8: 5N aq. sodium hydroxide / ethanol / 1.5 h / 20 °C

9: 35percent hydrogen peroxide / dimethylsulfoxide / 0.25 h / 15 °C

10: 91 percent / manganese(IV) oxide / tetrahydrofuran / 9 h / Ambient temperature

11: Pd/C / methanol / 760 Torr / Ambient temperature

12: 2.) NaBH₃CN / 1.) methanol, benzene, reflux, 6 h, 2.) methanol, benzene, RT, 24 h

With pyridine; hydrogenchloride; potassium cyanide; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; tetrafluoroboric acid; aluminium trichloride; dihydrogen peroxide; nitric acid; sodium cyanoborohydride; acetic acid; zinc; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019

Reference yield:

: 76139-03-2
2-chloro-1-(1-acetyl-2,3-dihydroindole-5-yl)ethanone

: 101565-18-8
5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)amino>ethyl>-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: dimethylformamide / 2 h / 60 °C

2: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

3: 94.5 percent / pyridine / Ambient temperature

4: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

5: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

6: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

7: 5N aq. sodium hydroxide / ethanol / 1.5 h / 20 °C

8: 35percent hydrogen peroxide / dimethylsulfoxide / 0.25 h / 15 °C

9: 91 percent / manganese(IV) oxide / tetrahydrofuran / 9 h / Ambient temperature

10: Pd/C / methanol / 760 Torr / Ambient temperature

11: 2.) NaBH₃CN / 1.) methanol, benzene, reflux, 6 h, 2.) methanol, benzene, RT, 24 h

With pyridine; hydrogenchloride; potassium cyanide; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; tetrafluoroboric acid; dihydrogen peroxide; nitric acid; sodium cyanoborohydride; acetic acid; zinc; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019

Reference yield:

: 101544-45-0
5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

: 101565-18-8
5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)amino>ethyl>-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Pd/C / methanol / 760 Torr / Ambient temperature

2: 2.) NaBH₃CN / 1.) methanol, benzene, reflux, 6 h, 2.) methanol, benzene, RT, 24 h

With sodium cyanoborohydride; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00156a019