(R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Base Information

Chemical Name:(R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol
CAS No.:114114-44-2
Molecular Formula:C₃₆H₅₀O₅Si
Molecular Weight:590.875
Hs Code.:

Synonyms:(R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Suppliers and Price of (R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

There total 24 articles about (R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 114114-43-1
(S)-3-[(2S,4R,5R,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1,1,1-triphenyl-butan-2-one

: 114114-44-2
(R)-2-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Guidance literature:: With lithium triethylborohydride;
DOI:10.1016/S0040-4039(00)96399-8

Reference yield: 90.0%

: 114114-43-1
(S)-3-[(4R,5R,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1,1,1-triphenyl-butan-2-one

: 114114-44-2
(R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; sodium triethylborohydride; lithium bromide; 1) THF, 20 deg C, 120 h, 2) water, room temperature, 2 h;
DOI:10.1007/BF00953634

Reference yield:

: 114114-40-8
tert-Butyl-[(1R,2R,3S,4R)-4-[1,3]dithian-2-yl-1-ethyl-3-(4-methoxy-benzyloxy)-2-methyl-pentyloxy]-diphenyl-silane

: 114114-44-2
(R)-2-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / CdCO₃, HgCl₂ / H₂O; acetone / 6 h / Heating

2: 1.) 0.7 N n-BuLi/hexane / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h

3: 85 percent / molecular sieves (3 Angstroem), DDQ / CH₂Cl₂ / 0.05 h / Ambient temperature

4: 90 percent / 1 N LiBHEt₃/THF / tetrahydrofuran / 120 h / Ambient temperature

With tetrahydrofuran; n-butyllithium; cadmium(II) carbonate; hexane; 3 A molecular sieve; lithium triethylborohydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; mercury dichloride; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)81090-5