tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane
CAS No.:114137-92-7
Molecular Formula:C₄₂H₅₄O₄SSi
Molecular Weight:683.04
Hs Code.:

Synonyms:tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

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Chemical Property of tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

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Technology Process of tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

There total 26 articles about tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 114114-44-2
(R)-2-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

: 882-33-7
diphenyldisulfane

: 114137-92-7
tert-Butyl-{(1R,2R)-1-ethyl-2-[(2S,4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

Guidance literature:: With tributylphosphine; In pyridine;
DOI:10.1016/S0040-4039(00)96399-8

Reference yield: 92.0%

: 114114-44-2
(R)-2-[(4S,5S,6R)-6-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-propan-1-ol

: 882-33-7
diphenyldisulfane

: 114137-92-7
tert-Butyl-{(1R,2R)-1-ethyl-2-[(4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

Guidance literature:: With pyridine; tributylphosphine; at 20 ℃; for 24h;
DOI:10.1007/BF00953634

Reference yield:

: 114114-41-9
(2R,3S,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptanal

: 114137-92-7
tert-Butyl-{(1R,2R)-1-ethyl-2-[(2S,4R,5R,6R)-2-(4-methoxy-phenyl)-5-methyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 0.7 N n-BuLi/hexane / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 1 h

2: 85 percent / molecular sieves (3 Angstroem), DDQ / CH₂Cl₂ / 0.05 h / Ambient temperature

3: 90 percent / 1 N LiBHEt₃/THF / tetrahydrofuran / 120 h / Ambient temperature

4: 92 percent / n-Bu₃P / pyridine / 22 h / Ambient temperature

With tetrahydrofuran; n-butyllithium; hexane; tributylphosphine; 3 A molecular sieve; lithium triethylborohydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)81090-5