3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester
CAS No.:1068968-22-8
Molecular Formula:C₂₃H₂₁N₅O₄
Molecular Weight:431.451
Hs Code.:

Synonyms:3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

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Chemical Property of 3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

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Technology Process of 3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

There total 8 articles about 3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 315492-81-0
1-amino-4-benzyloxycarbonyl-2-piperazinone

: 122774-00-9
2-phenylpyrimidine-5-carbonyl chloride

: 1068968-22-8
3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: 1-amino-4-benzyloxycarbonyl-2-piperazinone; 2-phenylpyrimidine-5-carbonyl chloride; In dichloromethane; N,N-dimethyl-formamide; for 16h;

With potassium hydrogencarbonate; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 318988-51-1
N-(2-oxoethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester

: 1068968-22-8
3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 15 h / Heating / reflux

2: sodium cyanoborohydride; acetic acid / acetonitrile / 5.5 h

3: diphenylether / 2 h / Heating / reflux

4: hydrazine / methanol / 3.5 h / Heating / reflux

5: dichloromethane; N,N-dimethyl-formamide / 16 h

With sodium cyanoborohydride; acetic acid; hydrazine; In 1,4-dioxane; methanol; diphenylether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1068974-91-3
(allyl-benzyloxycarbonyl-amino)-acetic acid ethyl ester

: 1068968-22-8
3-oxo-4-[(2-phenyl-pyrimidine-5-carbonyl)-amino]-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: AD-mix-β; water; tert-butyl alcohol / 22 h / 0 - 20 °C

2: SiO₂-supported NaIO₄ / dichloromethane / 4.5 h

3: 1,4-dioxane / 15 h / Heating / reflux

4: sodium cyanoborohydride; acetic acid / acetonitrile / 5.5 h

5: diphenylether / 2 h / Heating / reflux

6: hydrazine / methanol / 3.5 h / Heating / reflux

7: dichloromethane; N,N-dimethyl-formamide / 16 h

With AD-mix-β; SiO₂-supported NaIO₄; water; sodium cyanoborohydride; acetic acid; hydrazine; tert-butyl alcohol; In 1,4-dioxane; methanol; diphenylether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;