N₄-(4-hydroxybenzylidene)hydrazinoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide

Base Information

• Chemical Name: N₄-(4-hydroxybenzylidene)hydrazinoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide
• CAS No.: 1449513-53-4
• Molecular Formula: C₂₀H₂₁N₅O₅S
• Molecular Weight: 443.483

Synonyms:N₄-(4-hydroxybenzylidene)hydrazinoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide

Chemical Property of N₄-(4-hydroxybenzylidene)hydrazinoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide

Chemical Property:

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Technology Process of N₄-(4-hydroxybenzylidene)hydrazinoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide

There total 2 articles about N₄-(4-hydroxybenzylidene)hydrazinoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sulfisoxazole (127-69-5) → N4-(4-hydroxybenzylidene)hydrazinoacetylamino-N1-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide (1449513-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 12 h / Heating

2: hydrazine hydrate / ethanol / 10 h / Heating

3: acetic acid / ethanol / 8 h / Reflux

With potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; acetone;

DOI:10.3390/molecules18044140

Reference yield:

2-chloro-N-[4-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-phenyl]-acetamide (104246-33-5) → N4-(4-hydroxybenzylidene)hydrazinoacetylamino-N1-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide (1449513-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 10 h / Heating

2: acetic acid / ethanol / 8 h / Reflux

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.3390/molecules18044140

Reference yield: 55.0%

N4-(4-hydroxybenzylidene)hydrazinoacetylamino-N1-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide (1449513-53-4) + chloroacetyl chloride (79-04-9) → N4-[2-(4-hydroxyphenyl)-3-chloro-4-oxoazetidin-1-yl]aminoacetylamino-N1-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide (1449513-65-8)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 ℃; for 8h; Reflux;

DOI:10.3390/molecules18044140

upstream raw materials:

sulfisoxazole

2-chloro-N-[4-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-phenyl]-acetamide

Downstream raw materials:

N₄-[2-(4-hydroxyphenyl)-3-chloro-4-oxoazetidin-1-yl]aminoacetylamino-N₁-(3,4-dimethyl-1,2-oxazol-5-yl)benzensulfonamide

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