2-PHENYL-4,7-DIAZAINDOLE

Base Information

• Chemical Name: 2-PHENYL-4,7-DIAZAINDOLE
• CAS No.: 78605-10-4
• Molecular Formula: C12H9 N3
• Molecular Weight: 195.224
• Hs Code.: 2933990090
• Mol file: 78605-10-4.mol

Synonyms:4H-Pyrrolo[2,3-b]pyrazine, 6-phenyl- (9CI); 6-Phenyl-5H-pyrrolo[2,3-b]pyrazine; NSC 368287

Chemical Property of 2-PHENYL-4,7-DIAZAINDOLE

Chemical Property:

• Melting Point: 216 °C
• Boiling Point: °Cat760mmHg
• PKA: 11.73±0.20(Predicted)
• Flash Point: °C
• PSA: 41.57000
• Density: 1.27g/cm³
• LogP: 2.62490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Phenyl-5H-pyrrolo[2,3-B]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-4,7-DIAZAINDOLE

There total 18 articles about 2-PHENYL-4,7-DIAZAINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-bromo-6-phenyl-5H-pyrrolo[2,3-b]pyrazine → 2-Phenyl<1H>pyrrolo<2,3-b>pyrazine (78605-10-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; triethylsilane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; at 120 ℃; for 2h; Microwave irradiation;

DOI:10.1016/j.tetlet.2015.02.005

Reference yield: 67.0%

phenylacetylene (536-74-3) + N-(3-chloropyrazin-2-yl)-methanesulfonamide (724442-38-0) → 2-Phenyl<1H>pyrrolo<2,3-b>pyrazine (78605-10-4)

Guidance literature:

With sodium carbonate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.1016/j.tetlet.2004.08.155

Reference yield: 60.0%

3-phenylethynyl-pyrazin-2-ylamine (798544-32-8) → 2-Phenyl<1H>pyrrolo<2,3-b>pyrazine (78605-10-4)

Guidance literature:

With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 70 ℃;

DOI:10.1016/j.tetlet.2004.08.155

upstream raw materials:

2-Methylpyrazine

benzonitrile

phenylacetylene

N-(3-chloropyrazin-2-yl)-methanesulfonamide

Downstream raw materials:

1,3,7-triphenyl-3H-pyrrolo[2,3-e]-1,2,4-triazolo[4,3-a]pyrazine

1,3,7-triphenyl-5,6-dihydro-3H-pyrrolo[2,3-e]-1,2,4-triazolo[4,3-a]pyrazine

1,3,7-triphenyl-6-[1-phenyl-N-phenyl-2-ethanehydrazonyl]-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine

1-acetyl-3,7-diphenyl-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine

Refernces

• 1、 Simpson, Iain,St-Gallay, Steve A.,Stokes, Stephen,Whittaker, David T.E.,Wiewiora, Rafal. "An efficient one-pot synthesis of 2-bromo-6-aryl[5H]pyrrolo[2,3-b]pyrazines". . p. 1492 - 1495. Retrieved 2015/03/14.
• 2、 Hopkins, Corey R.,Collar, Nicola. "An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating". . p. 8631 - 8633. Retrieved 2007/10/03.