4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

Base Information

Chemical Name:4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde
CAS No.:877142-03-5
Molecular Formula:C₃₈H₃₉N₃O₂
Molecular Weight:569.747
Hs Code.:

4-{3-[4-(1-trityl-1<i>H</i>-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

Synonyms:4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

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Chemical Property of 4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

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Technology Process of 4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

There total 7 articles about 4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 877142-02-4
3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propan-1-ol

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 877142-03-5
4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.10.087

Reference yield:

: 224168-76-7
acetic acid pyridin-4-yl-(1-trityl-1H-imidazol-4-yl)-methyl ester

: 877142-03-5
4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂; AcOH / PtO₂ / 3102.89 Torr

2: methanol

3: LiAlH₄ / tetrahydrofuran

4: 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

With lithium aluminium tetrahydride; tributylphosphine; hydrogen; acetic acid; 1,1'-azodicarbonyl-dipiperidine; platinum(IV) oxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.09.076

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 877142-03-5
4-{3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propoxy}-benzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: CH₂Cl₂

1.2: 100 percent / CH₂Cl₂

2.1: 85 percent / DMAP / CH₂Cl₂

3.1: 96 percent / H₂; AcOH / PtO₂ / 3102.89 Torr

4.1: methanol

5.1: LiAlH₄ / tetrahydrofuran

6.1: 1,1'-(azodicarbonyl)dipiperidine; Bu₃P / tetrahydrofuran

With dmap; lithium aluminium tetrahydride; tributylphosphine; hydrogen; acetic acid; 1,1'-azodicarbonyl-dipiperidine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.09.076