tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

Chemical Name:tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:1421244-86-1
Molecular Formula:C₆₂H₉₄N₆O₁₃
Molecular Weight:1131.46
Hs Code.:

tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Synonyms:tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 7 articles about tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1421244-85-0
4-((4-(2-(16-(2-(1,4,7,10-tetraazacyclododecan-1-yl)acetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

: 1421244-86-1
tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; for 20h;
DOI:10.1002/chem.201202925

Reference yield:

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 1421244-86-1
tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1,4-dioxane / 26 h / 20 - 40 °C

2: caesium carbonate / acetonitrile / 25 h / 20 - 65 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

6: caesium carbonate / acetonitrile / 20 - 60 °C

7: caesium carbonate / acetonitrile / 20 h / 20 °C

With caesium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201202925

Reference yield:

: 1421244-83-8
4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

: 1421244-86-1
tert-butyl 2,2',2-(10-(2-oxo-2-(16-(4-((4-benzophenonyl)methoxy)phenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)ethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 20 - 60 °C

2: caesium carbonate / acetonitrile / 20 h / 20 °C

With caesium carbonate; In acetonitrile;
DOI:10.1002/chem.201202925