4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

Base Information

Chemical Name:4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone
CAS No.:1421244-83-8
Molecular Formula:C₃₆H₄₅ClN₂O₇
Molecular Weight:653.216
Hs Code.:

Synonyms:4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

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Chemical Property of 4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

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Technology Process of 4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

There total 4 articles about 4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.4%

: 1421244-80-5
4-((4-(2-(1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

: 79-04-9
chloroacetyl chloride

: 1421244-83-8
4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/chem.201202925

Reference yield:

: 231304-42-0
1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane-7-carboxylic acid tert-butyl ester

: 1421244-83-8
4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 25 h / 20 - 65 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With caesium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201202925

Reference yield:

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 1421244-83-8
4-((4-(2-(16-(2-chloroacetyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-yl)ethyl)phenoxy)methyl)benzophenone

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 26 h / 20 - 40 °C

2: caesium carbonate / acetonitrile / 25 h / 20 - 65 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: triethylamine / dichloromethane / 0 - 20 °C

With caesium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201202925