1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole

Base Information

• Chemical Name: 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole
• CAS No.: 1445874-25-8
• Molecular Formula: C₁₈H₁₂ClF₄NO
• Molecular Weight: 369.746

Synonyms:1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole

Chemical Property of 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole

Chemical Property:

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Technology Process of 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole

There total 2 articles about 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(trifluoromethoxy)aniline (461-82-5) + 1-(4-chloro-3-fluorophenyl)-1,4-pentanedione (1247508-21-9) → 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole (1445874-25-8)

Guidance literature:

With gadolinium(III) trifluoromethanesulfonate; In acetonitrile; at 30 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2013.03.027

Reference yield:

4-chloro-3-fluorobenzaldehyde (5527-95-7) → 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole (1445874-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 5 h / 75 - 78 °C

2: gadolinium(III) trifluoromethanesulfonate / acetonitrile / 0.5 h / 30 °C

With triethylamine; gadolinium(III) trifluoromethanesulfonate; In acetonitrile; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis;

DOI:10.1016/j.ejmech.2013.03.027

Reference yield: 80.0%

(R)-5-(azidomethyl)-3-(3-fluoro-4-(piperazin-1-yl)phenyl)oxazolidin-2-one (221201-21-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-(4-trifluoromethoxyphenyl)-2-methyl-5-(4-chloro-3-fluorophenyl)pyrrole (1445874-25-8) → (R)-5-(azidomethyl)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one (1445874-32-7)

Guidance literature:

With acetic acid; In water; acetonitrile; at 0 - 30 ℃; for 6h;

DOI:10.1016/j.ejmech.2013.03.027

upstream raw materials:

4-chloro-3-fluorobenzaldehyde

4-(trifluoromethoxy)aniline

1-(4-chloro-3-fluorophenyl)-1,4-pentanedione

Downstream raw materials:

(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

(R)-5-(azidomethyl)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

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