(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

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Chemical Name:(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one
CAS No.:1445874-50-9
Molecular Formula:C₄₁H₃₅ClF₅N₇O₃
Molecular Weight:804.219
Hs Code.:

(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Synonyms:(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

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Chemical Property of (R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

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Technology Process of (R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

There total 4 articles about (R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1445874-32-7
(R)-5-(azidomethyl)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)oxazolidin-2-one

: 536-74-3
phenylacetylene

: 1445874-50-9
(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 30 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.03.027

Reference yield:

: 5527-95-7
4-chloro-3-fluorobenzaldehyde

: 1445874-50-9
(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 5 h / 75 - 78 °C

2: gadolinium(III) trifluoromethanesulfonate / acetonitrile / 0.5 h / 30 °C

3: acetic acid / acetonitrile; water / 6 h / 0 - 30 °C

4: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 4 h / 30 °C

With copper(II) sulfate; acetic acid; sodium L-ascorbate; triethylamine; gadolinium(III) trifluoromethanesulfonate; In water; acetonitrile; tert-butyl alcohol; 1: |Stetter 1,4-Dicarbonyl Synthesis / 2: |Paal-Knorr Pyrrole Synthesis / 3: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.03.027

Reference yield:

: 1247508-21-9
1-(4-chloro-3-fluorophenyl)-1,4-pentanedione

: 1445874-50-9
(R)-3-(4-(4-((5-(4-chloro-3-fluorophenyl)-2-methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methyl)piperazin-1-yl)-3-fluorophenyl)-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: gadolinium(III) trifluoromethanesulfonate / acetonitrile / 0.5 h / 30 °C

2: acetic acid / acetonitrile; water / 6 h / 0 - 30 °C

3: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 4 h / 30 °C

With copper(II) sulfate; acetic acid; sodium L-ascorbate; gadolinium(III) trifluoromethanesulfonate; In water; acetonitrile; tert-butyl alcohol; 1: |Paal-Knorr Pyrrole Synthesis / 2: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.03.027