3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

Base Information

Chemical Name:3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate
CAS No.:1361968-37-7
Molecular Formula:C₂₇H₂₂F₃N₃O₄
Molecular Weight:509.485
Hs Code.:

Synonyms:3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

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Chemical Property of 3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

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Technology Process of 3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

There total 6 articles about 3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 1361967-00-1
SL-2-25

: 1361968-37-7
3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

Guidance literature:: SL-2-25; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

4-morpholinocarbonyl chloride; In tetrahydrofuran; for 2h;
DOI:10.1021/jm201184h

Reference yield:

: 1361968-43-5
1-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-1-ol

: 1361968-37-7
3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

3.2: 2 h

With potassium tert-butylate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; butan-1-ol;
DOI:10.1021/jm201184h

Reference yield:

: 63478-10-4
2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1361968-37-7
3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)quinolin-4-ylmorpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 2 h

With potassium tert-butylate; toluene-4-sulfonic acid; In tetrahydrofuran; butan-1-ol;
DOI:10.1021/jm201184h