N-Hydroxyphenacetin

Base Information

• Chemical Name: N-Hydroxyphenacetin
• CAS No.: 19315-64-1
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Hs Code.: 2924299090
• NSC Number: 229647
• UNII: BX808PYL73
• DSSTox Substance ID: DTXSID80172916
• Nikkaji Number: J3.457F
• Wikidata: Q83042989
• Mol file: 19315-64-1.mol

Synonyms:N-hydroxyphenacetin;N-hydroxyphenacetin, 1-(14)C-labeled cpd;N-hydroxyphenacetin, 2-hydroxy isomer;N-hydroxyphenacetin, 3-hydroxy isomer

Chemical Property of N-Hydroxyphenacetin

Chemical Property:

• Vapor Pressure: 2.33E-05mmHg at 25°C
• Refractive Index: 1.5150 (estimate)
• Boiling Point: 345.5°Cat760mmHg
• Flash Point: 162.7°C
• PSA: 49.77000
• Density: 1.2g/cm³
• LogP: 1.82740
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

N-(4-ETHOXYPHENYL)-N-HYDROXYACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)N(C(=O)C)O

Technology Process of N-Hydroxyphenacetin

There total 3 articles about N-Hydroxyphenacetin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-hydroxyphenetidine (38246-95-6) + acetyl chloride (75-36-5) → N-hydroxyphenacetin (19315-64-1)

Guidance literature:

In diethyl ether; for 1h;

DOI:10.1124/dmd.118.082453

Reference yield:

1-ethoxy-4-nitrobenzene (100-29-8) → N-hydroxyphenacetin (19315-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; ammonium chloride / ethanol; water / 0.17 h / 20 °C

2: diethyl ether / 1 h

With ammonium chloride; zinc; In diethyl ether; ethanol; water;

DOI:10.1124/dmd.118.082453

Reference yield:

→ N-hydroxyphenacetin (19315-64-1)

Guidance literature:

N-(4-Ethoxyphenyl)-hydroxylamin, Keten;

DOI:10.1039/c39720000891

upstream raw materials:

N-hydroxyphenetidine

acetyl chloride

1-ethoxy-4-nitrobenzene

Downstream raw materials:

N-hydroxyphenetidine