Axamozide

Base Information

• Chemical Name: Axamozide
• CAS No.: 85076-06-8
• Molecular Formula: C21H22ClN3O3
• Molecular Weight: 399.8707
• Mol file: 85076-06-8.mol

Synonyms:Axamozide [INN];Axamozide;Axamozidum;UNII-MCG9O55T6K;

Chemical Property of Axamozide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 59.75000
• Density: 1.345g/cm³
• LogP: 3.81010

Purity/Quality:

AXAMOZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Axamozide

There total 6 articles about Axamozide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine (2164-34-3) + 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (53786-28-0) → axamozide (85076-06-8)

Guidance literature:

With triethylamine; sodium iodide; In N,N-dimethyl-formamide; for 60h; Ambient temperature;

DOI:10.1021/jm00388a012

Reference yield:

ethyl 4-aminopiperidine-1-carboxylate (58859-46-4) → axamozide (85076-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 65 percent / Na₂CO₃, KI / various solvent(s) / 28 h / 160 °C

2: 93 percent / H₂ / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature

3: 90 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

4: 96 percent / 10percent NaOH / 8 h / Heating

5: 60 percent / Et₃N, NaI / dimethylformamide / 60 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium carbonate; triethylamine; potassium iodide; sodium iodide; nickel; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00388a012

Reference yield:

4-(4-chloro-2-nitro-anilino)-piperidine-1-carboxylic acid ethyl ester (53786-44-0) → axamozide (85076-06-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / H₂ / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature

2: 90 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: 96 percent / 10percent NaOH / 8 h / Heating

4: 60 percent / Et₃N, NaI / dimethylformamide / 60 h / Ambient temperature

With sodium hydroxide; hydrogen; triethylamine; sodium iodide; nickel; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00388a012

upstream raw materials:

2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine

5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

ethyl 4-aminopiperidine-1-carboxylate

ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate

Refernces