53786-44-0 Usage
General Description
Ethyl 4-[(4-chloro-2-nitrophenyl)amino]piperidine-1-carboxylate, also known as Nocodazole, is a synthetic compound used in cell biology research as a microtubule destabilizing agent. It is commonly used to arrest cells in mitosis and has been found to disrupt microtubule dynamics by binding to tubulin, causing mitotic arrest. ethyl 4-[(4-chloro-2-nitrophenyl)amino]piperidine-1-carboxylate has been utilized in various studies to understand the role of microtubules in cell division and development, as well as in the treatment of certain types of cancer. Its chemical structure contains an ethyl ester, a piperidine ring, and a nitrophenyl amino group, making it a valuable tool in the study of cellular processes and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 53786-44-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,8 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 53786-44:
(7*5)+(6*3)+(5*7)+(4*8)+(3*6)+(2*4)+(1*4)=150
150 % 10 = 0
So 53786-44-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H18ClN3O4/c1-2-22-14(19)17-7-5-11(6-8-17)16-12-4-3-10(15)9-13(12)18(20)21/h3-4,9,11,16H,2,5-8H2,1H3
53786-44-0Relevant articles and documents
Method for synthesizing ethyl 4-[(2-amino-4-chloro)phenyl]-amino-N-piperidinecarboxylate
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Paragraph 0007; 0020-0022; 0026-0028; 0030-0032; 0034-0036, (2018/09/08)
The invention provides a method for synthesizing ethyl 4-[(2-amino-4-chloro)phenyl]-amino-N-piperidinecarboxylate. A reaction route of the method is as described in the specification. The invention has the following beneficial effects: 1, the novel synthetic method is designed in the invention for preparation of a domperidone intermediate with a structure as shown in a formula (DP-2) and is implemented, and the method uses easily available raw materials and is high in safety coefficient, simple in reaction and beneficial for realizing of large-scale industrial production; and 2, no special production equipment is need in the method, industrial scale-up production can be easily carried out, and production cost for the domperidone intermediate is greatly lowered, so production cost for domperidone is substantially reduced.
Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzimidazolone derivatives
Henning,Lattrell,Gerhards,Leven
, p. 814 - 820 (2007/10/02)
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