2-Amino-2-thiazoline

Base Information

• Chemical Name: 2-Amino-2-thiazoline
• CAS No.: 1779-81-3
• Deprecated CAS: 13577-63-4,64321-55-7,78788-13-3,64321-55-7,78788-13-3
• Molecular Formula: C3H6 N2 S
• Molecular Weight: 102.16
• Hs Code.: 29341000
• European Community (EC) Number: 217-224-1
• NSC Number: 24626,3110
• UNII: 5JC2YZG56Q
• DSSTox Substance ID: DTXSID4061961
• Nikkaji Number: J48.823B
• Wikidata: Q27093350
• Pharos Ligand ID: 1UUT21HMLLY8
• Metabolomics Workbench ID: 146927
• ChEMBL ID: CHEMBL362148
• Mol file: 1779-81-3.mol

Synonyms:2-amino-2-thiazoline;2-Amino-4-thiazoline;2-aminothiazoline;2-aminothiazoline monohydrobromide;2-aminothiazoline nitrate;2-aminothiazoline phosphate;2-aminothiazoline sulfate;Revercan

Chemical Property of 2-Amino-2-thiazoline

Chemical Property:

• Appearance/Colour: White crystalline powder.
• Vapor Pressure: 0.105mmHg at 25°C
• Melting Point: 79-82 ºC
• Refractive Index: 1.5500 (estimate)
• Boiling Point: 221.8 °C at 760 mmHg
• PKA: 8.04±0.10(Predicted)
• Flash Point: 87.9 °C
• PSA: 63.68000
• Density: 1.5 g/cm³
• LogP: 0.18380
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in water.
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 102.02516937
• Heavy Atom Count: 6
• Complexity: 78.9

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2-thiazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSC(=N1)N
• Uses: 2-Amino-2-thiazoline is used as radiation protectants.

Technology Process of 2-Amino-2-thiazoline

There total 17 articles about 2-Amino-2-thiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromoethylamine hydrobromide (2576-47-8) + thiourea (17356-08-0) → 4,5-Dihydro-thiazol-2-ylamin (1779-81-3)

Guidance literature:

2-bromoethylamine hydrobromide; thiourea; In water; at 60 - 70 ℃; for 2.5h;

With sodium carbonate; In water;

DOI:10.1039/c1gc15285h

Reference yield: 69.0%

ethyleneimine (151-56-4,9002-98-6) + thiourea (17356-08-0) → 2-imino-2,3,4,5-tetrahydrothiazole (1779-81-3)

Guidance literature:

With sulfuric acid; 1) 1.5 h, 5 deg C, 2) 2 h, reflux;

Reference yield:

2,2'-dithio-bis[ethylamine] (51-85-4) + potassium cyanide (151-50-8) → 4,5-Dihydro-thiazol-2-ylamin (1779-81-3) + Cysteamine (60-23-1)

Guidance literature:

upstream raw materials:

2,2'-dithio-bis[ethylamine]

potassium cyanide

2-chloroethanamine hydrochloride

potassium thioacyanate

Downstream raw materials:

3-benzoyl-2-benzoylimino-thiazolidine

N-acetyl-sulfanilic acid-[3-(N-acetyl-sulfanilyl)-thiazolidin-2-ylidenamide]

2-Ureido-Δ²-thiazolin

N-(4,5-dihydro-thiazol-2-yl)-acetamide

Refernces

• 1、 -. "Tebipenem pivoxil intermediate and synthesis method and application thereof". Paragraph 0050-0053. . Retrieved 2020/02/14.
• 2、 Shankaran,Donnelly, Karla L.,Shah, Shrenik K.,Guthikonda, Ravindra N.,MacCoss, Malcolm,Humes, John L.,Pacholok, Stephen G.,Grant, Stephan K.,Kelly,Wong. "Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase". . p. 4539 - 4544. Retrieved 2007/10/03.