(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

Base Information

Chemical Name:(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester
CAS No.:1434815-79-8
Molecular Formula:C₂₀H₂₃ClFNO₃
Molecular Weight:379.859
Hs Code.:

Synonyms:(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

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Chemical Property of (R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

Chemical Property:

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Technology Process of (R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

There total 8 articles about (R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623-43-8
crotonic acid methyl ester

: 1434725-41-3
(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

: 1434815-79-8
(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

: (R)-3-[(S)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

Guidance literature:: (R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride; With sodium hydrogencarbonate; In chloroform;

crotonic acid methyl ester; for 24h; Inert atmosphere; Reflux;

Reference yield:

: 765302-73-6
1-chloro-3-fluoro-4-methyl-2-phenoxybenzene

: 1434815-79-8
(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

: (R)-3-[(S)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

2.1: silver nitrate / isopropyl alcohol; water / 2 h

3.1: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

4.1: tetrahydrofuran / 3 h / -70 °C

5.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h

6.1: sodium hydrogencarbonate / chloroform

6.2: 24 h / Inert atmosphere; Reflux

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; silver nitrate; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; chloroform; water; isopropyl alcohol;

Reference yield:

: 2-trimethylsilyloxyphenyl triflate

: 1434815-79-8
(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

: (R)-3-[(S)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: cesium fluoride / acetonitrile / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

3.1: silver nitrate / isopropyl alcohol; water / 2 h

4.1: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

5.1: tetrahydrofuran / 3 h / -70 °C

6.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h

7.1: sodium hydrogencarbonate / chloroform

7.2: 24 h / Inert atmosphere; Reflux

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; silver nitrate; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; chloroform; water; isopropyl alcohol; acetonitrile;