(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester
CAS No.:1370259-81-6
Molecular Formula:C₂₇H₄₂N₆O₂
Molecular Weight:482.669
Hs Code.:

Synonyms:(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

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Chemical Property of (4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

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Technology Process of (4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

There total 9 articles about (4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1370259-89-4
(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-3-oxopropyl}phenyl)carbamic acid tert-butyl ester

: 1370259-81-6
(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3.25h; Cooling with ice;
DOI:10.1039/c2ob06801j

Reference yield:

: 423165-07-5
UK-408027

: 1370259-81-6
(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / Inert atmosphere; Cooling with ice; Molecular sieve

1.2: 4 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 20 °C / 3102.97 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.25 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c2ob06801j

Reference yield:

: 3-(4-aminophenyl)acrylic acid isopropyl ester

: 1370259-81-6
(4-{1-amino-3-[3-(3-isopropyl-5-methyl-[1,2,4]triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}phenyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 2 h / -78 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 48 h / Reflux

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.25 h / Inert atmosphere; Cooling with ice; Molecular sieve

4.2: 4 h / 20 °C / Inert atmosphere; Molecular sieve

5.1: palladium 10% on activated carbon; hydrogen / methanol / 96 h / 20 °C / 3102.97 Torr

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.25 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; n-butyllithium; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water;
DOI:10.1039/c2ob06801j