3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

Base Information

Chemical Name:3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester
CAS No.:1370259-85-0
Molecular Formula:C₃₂H₄₀N₂O₄
Molecular Weight:516.681
Hs Code.:

Synonyms:3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

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Chemical Property of 3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

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Technology Process of 3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

There total 8 articles about 3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370259-84-9
3-(4-tert-butoxycarbonylamino-phenyl)-acrylic acid isopropyl ester

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 1370259-85-0
3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere; Cooling with ice;

3-(4-tert-butoxycarbonylamino-phenyl)-acrylic acid isopropyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 2h; diastereoselective reaction;

Reference yield:

: 3-(4-tert-butoxycarbonylaminophenyl)acrylic acid isopropyl ester

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 1370259-85-0
3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; for 0.5h; Inert atmosphere; Cooling with ice;

3-(4-tert-butoxycarbonylaminophenyl)acrylic acid isopropyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c2ob06801j

Reference yield:

: 3-(4-aminophenyl)acrylic acid isopropyl ester

: 1370259-85-0
3-[benzyl-(1-phenyl-ethyl)-amino-3-(4-tert-butoxycarbonylamino-phenyl)]-propionic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1039/c2ob06801j