dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

Base Information

Chemical Name:dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate
CAS No.:771562-91-5
Molecular Formula:C₁₉H₂₅NO₈
Molecular Weight:395.409
Hs Code.:

Synonyms:dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

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Chemical Property of dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

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Technology Process of dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

There total 4 articles about dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108-59-8
malonic acid dimethyl ester

: 133332-47-5
2-(cyclopentyloxy)-1-methoxy-4-[(E)-2-nitroethenyl]benzene

: 771562-91-5
dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

Guidance literature:: With 1-(3,5-Bis-trifluoromethyl-phenyl)-3-[(R)-quinolin-4-yl-((2R,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-thiourea; In dichloromethane; at -20 - 0 ℃; for 96h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol800108u

Reference yield: 87.0%

: 141332-74-3
2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

: 108-59-8
malonic acid dimethyl ester

: 771562-91-5
dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

Guidance literature:: With 1-{3,5-bis(trifluoromethyl)phenyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea; In toluene; at 10 ℃; for 168h; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.mencom.2016.11.003

Reference yield:

: 108-59-8
malonic acid dimethyl ester

: 133332-47-5
2-(cyclopentyloxy)-1-methoxy-4-[(E)-2-nitroethenyl]benzene

: (S)-methyl 2-carbomethoxy-4-nitro-3-(3-cyclopentyloxy-4-methoxyphenyl)butyrate

: 771562-91-5
dimethyl [(1R)-1-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-nitroethyl]propanedioate

Guidance literature:: With Ru[(1S,2S)-N-SO₂PhMe₅-1,2-Ph₂-ethylenediamine]; In toluene; at -20 ℃; for 48h; Title compound not separated from byproducts;
DOI:10.1021/ja046296g