[(2S)-1-phenylpropan-2-yl]azanium;chloride

Base Information

• Chemical Name: [(2S)-1-phenylpropan-2-yl]azanium;chloride
• CAS No.: 1462-73-3
• Molecular Formula: C9H13N.ClH
• Molecular Weight: 171.67
• Hs Code.: 2923900090
• Mol file: 1462-73-3.mol

Synonyms:

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Chemical Property of [(2S)-1-phenylpropan-2-yl]azanium;chloride

Chemical Property:

• Vapor Pressure: 0.307mmHg at 25°C
• Melting Point: 151-153°C
• Boiling Point: 201.5 °C at 760 mmHg
• Flash Point: 87.4 °C
• PSA: 26.02000
• LogP: 3.07860
• Storage Temp.: Controlled Substance, -20°C Freezer
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 171.0814771
• Heavy Atom Count: 11
• Complexity: 84.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)[NH3+].[Cl-]
• Isomeric SMILES: C[C@@H](CC1=CC=CC=C1)[NH3+].[Cl-]
• Description: D-Amphetamine (hydrochloride) (exempt preparation) (Item No. 15650) is an analytical reference standard categorized as an amphetamine. Amphetamine is a psychotropic compound that is abused recreationally. Amphetamine is regulated as a Schedule II compound in the United States. D-Amphetamine (hydrochloride) (exempt preparation) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
• Uses: CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake. Controlled substance (stimulant).

Technology Process of [(2S)-1-phenylpropan-2-yl]azanium;chloride

There total 24 articles about [(2S)-1-phenylpropan-2-yl]azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-(-)-2-ethoxycarbonylamino-1-phenylpropane (26343-76-0) → (S)-(+)-amphetamine hydrochloride (1462-73-3,405-41-4)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1021/ja00410a030

Reference yield: 91.0%

tert-butyl (1S)-1-methyl-2-phenylethyl carbamate (293305-71-2) → (S)-(+)-amphetamine hydrochloride (1462-73-3,405-41-4)

Guidance literature:

tert-butyl (1S)-1-methyl-2-phenylethyl carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

With hydrogenchloride; In diethyl ether; chloroform; Further stages.;

DOI:10.1021/jo000242h

Reference yield: 70.0%

(1R,2S)-(-)-norephedrine hydrochloride (3198-15-0) → (S)-(+)-amphetamine hydrochloride (1462-73-3,405-41-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 20h; under 3102.97 Torr; enantioselective reaction;

DOI:10.1016/j.tetlet.2015.10.010

upstream raw materials:

norephedine

(S)-(-)-2-ethoxycarbonylamino-1-phenylpropane

(S)-2,9,9-Trimethyl-4-((S)-1-methyl-2-phenyl-ethyl)-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]decane

(S,S)-(-)-N-(1-phenylethyl)-1-phenyl-2-aminopropane hydrochloride

Downstream raw materials:

Pentanoyl-(+)-amphetamin

Isopentanoyl-(+)-amphetamin

N-<(S)-1-methyl-2-phenylethyl>formamide

Laevulinoyl-(+)-amphetamin