L,L-homocystine

Base Information

• Chemical Name: L,L-homocystine
• CAS No.: 870-93-9
• Molecular Formula: C₈H₁₆N₂O₄S₂
• Molecular Weight: 268.358
• Hs Code.: 2930909090
• Wikidata: Q102047821
• Mol file: 870-93-9.mol

Synonyms:L,L-homocystine;L-homocystine zwitterion;L,L-homocystine zwitterion;CHEBI:140613

Chemical Property of L,L-homocystine

Chemical Property:

• Appearance/Colour: white to slightly beige solid
• Melting Point: ≥300 °C
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 507.6 °C at 760 mmHg
• PKA: 1.90±0.10(Predicted)
• Flash Point: 260.8 °C
• PSA: 177.24000
• Density: 1.443 g/cm³
• LogP: 1.37240
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: 0.2g/L(25 oC)
• XLogP3: -4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 268.05514934
• Heavy Atom Count: 16
• Complexity: 205

Purity/Quality:

98%min ^*data from raw suppliers

DL-Homocystine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CSSCCC(C(=O)[O-])[NH3+])C(C(=O)[O-])[NH3+]
• Isomeric SMILES: C(CSSCC[C@@H](C(=O)[O-])[NH3+])[C@@H](C(=O)[O-])[NH3+]

Technology Process of L,L-homocystine

There total 7 articles about L,L-homocystine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

L-homocysteine (6027-13-0) → L-homocystine (626-72-2,870-93-9,6027-15-2,7093-69-8,462-10-2)

Guidance literature:

With dihydrogen peroxide; for 8h;

DOI:10.1246/bcsj.66.536

Reference yield: 43.0%

L-methionine (63-68-3,26062-47-5,58576-49-1) → L-homocystine (626-72-2,870-93-9,6027-15-2,7093-69-8,462-10-2)

Guidance literature:

L-methionine; With ammonia; lithium; at -78 ℃; for 1.5h;

With dihydrogen peroxide; In water; Cooling with ice;

Reference yield:

S-benzyl-L-homocysteine (7689-60-3,3054-02-2) → L-homocystine (626-72-2,870-93-9,6027-15-2,7093-69-8,462-10-2)

Guidance literature:

With ammonia; sodium; Einwirkung von Luft das gebildete Natriumsalz des L-Homocysteins in wss.Loesung unter Zusatz von FeCl₃;

upstream raw materials:

S-benzyl-L-homocysteine

L-homocysteine

(S)-2-Amino-4-[(R)-2-((S)-3-amino-3-carboxy-propyldisulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

S-nitroso-L-homocysteine

Downstream raw materials:

S-(5'-adenosyl)-L-homocysteine

Fmoc-L-homocystine

(S)-2-Amino-4-[(2S,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-butyric acid

dimethyl 4,4'-disulfanediyl(2S,2'S)-bis(2-((tert-butoxycarbonyl)amino)butanoate)

Refernces

• 1、 Ghosh, Sourav,Roy, Punarbasu,Prasad, Sanjay,Mugesh, Govindasamy. "Crystal-facet-dependent denitrosylation: Modulation of NO release from S-nitrosothiols by Cu2O polymorphs". . p. 5308 - 5318. Retrieved 2019/05/29.
• 2、 -. "Colorimetric and fluorometric determination of homocysteine and cysteine". Page/Page column 8; 9. . Retrieved 2015/12/18.