C₃₁H₃₁N₃O₉S

Base Information

• Chemical Name: C₃₁H₃₁N₃O₉S
• CAS No.: 1388218-55-0
• Molecular Formula: C₃₁H₃₁N₃O₉S
• Molecular Weight: 621.668
• Mol file: 1388218-55-0.mol

Synonyms:C₃₁H₃₁N₃O₉S

Chemical Property of C₃₁H₃₁N₃O₉S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₃₁N₃O₉S

There total 4 articles about C₃₁H₃₁N₃O₉S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4β-isothiocyanate-4-deoxypodophyllotoxin (1374432-04-8) + 4-methoxybenzoic acid hydrazide (3290-99-1) → C31H31N3O9S (1388218-55-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2012.05.059

Reference yield:

4β-amino-4-deoxypodophyllotoxin (155252-35-0) → C31H31N3O9S (1388218-55-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1.5 h / 0 - 20 °C

2: p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

3: tetrahydrofuran / 20 °C

With triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.05.059

Reference yield:

podofilox (518-28-5) → C31H31N3O9S (1388218-55-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium azide; trifluoroacetic acid / chloroform / 5 h / 20 °C / Cooling with ice

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

3: triethylamine / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

5: tetrahydrofuran / 20 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; chloroform;

DOI:10.1016/j.bmcl.2012.05.059

upstream raw materials:

4β-isothiocyanate-4-deoxypodophyllotoxin

4-methoxybenzoic acid hydrazide

4β-amino-4-deoxypodophyllotoxin

podofilox

Downstream raw materials:

4β-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin