1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride

Base Information

• Chemical Name: 1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride
• CAS No.: 1400670-07-6
• Molecular Formula: C₂₃H₂₆ClN₉*ClH
• Molecular Weight: 500.434

Synonyms:1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride

Chemical Property of 1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride

There total 8 articles about 1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-(3-chloro-phenyl)-2-{4-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-ethyl)-carbamic acid tert-butyl ester (1400670-54-3) → 1-(3-chlorophenyl)-N1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride (1400670-07-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 15h;

Reference yield:

1-methyl-piperazine (109-01-3) → 1-(3-chlorophenyl)-N1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride (1400670-07-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

3: 2 h / 140 °C

4: hydrogenchloride / ethanol; water / 15 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

[2-(3-Chloro-phenyl)-2-(1,3-di oxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid tert-butyl ester (1386398-77-1) → 1-(3-chlorophenyl)-N1-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride (1400670-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / water; tetrahydrofuran; methanol / 1 h / 55 °C

2: 2 h / 140 °C

3: hydrogenchloride / ethanol; water / 15 h / 20 °C

With hydrogenchloride; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; water;

upstream raw materials:

1-methyl-piperazine

2-amino-1-(3-chloro-phenyl)-ethanol

2-(3-chlorophenyl)-2-hydroxyacetonitrile

[2-amino-2-(3-chloro-phenyl)-ethyl]-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1400670-07-6 1-(3-chlorophenyl)-N₁-{4-[8-(4-methylpiperazin-1-yl)imidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-yl}ethane-1,2-diamine hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send