N-[2-AMINO-2-(3-CHLOROPHENYL)ETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: N-[2-AMINO-2-(3-CHLOROPHENYL)ETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 1047630-73-8
• Molecular Formula: C13H19ClN2O2
• Molecular Weight: 270.759
• Hs Code.: 2924299090
• Mol file: 1047630-73-8.mol

Synonyms:N-[2-AMINO-2-(3-CHLOROPHENYL)ETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER;2-(Boc-amino)-1-(3-chlorophenyl)ethylamine

Chemical Property of N-[2-AMINO-2-(3-CHLOROPHENYL)ETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 67.84000
• LogP: 3.76920

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(2-amino-2-(3-chlorophenyl)ethyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-AMINO-2-(3-CHLOROPHENYL)ETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

There total 6 articles about N-[2-AMINO-2-(3-CHLOROPHENYL)ETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

[2-(3-Chloro-phenyl)-2-(1,3-di oxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbamic acid tert-butyl ester (1386398-77-1) → [2-amino-2-(3-chloro-phenyl)-ethyl]-carbamic acid tert-butyl ester (1047630-73-8)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; methanol; at 55 ℃; for 1h;

Reference yield:

2-(3-chlorophenyl)-2-hydroxyacetonitrile (97070-75-2,122047-10-3,137766-66-6,53313-92-1) → [2-amino-2-(3-chloro-phenyl)-ethyl]-carbamic acid tert-butyl ester (1047630-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride; sodium hydroxide / tetrahydrofuran

2: tetrahydrofuran

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

4: hydrazine hydrate / water; tetrahydrofuran; methanol

With sodium hydroxide; lithium aluminium tetrahydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water;

Reference yield:

[2-(3-chloro-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester (1187983-89-6) → [2-amino-2-(3-chloro-phenyl)-ethyl]-carbamic acid tert-butyl ester (1047630-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

2: hydrazine hydrate / water; tetrahydrofuran; methanol

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water;

upstream raw materials:

m-Chlorobenzaldehyde

2-amino-1-(3-chloro-phenyl)-ethanol

2-(3-chlorophenyl)-2-hydroxyacetonitrile

[2-(3-chloro-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

Downstream raw materials:

[2-{4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-2-(3-chloro-phenyl)-ethyl]-carbamic acid tert-butyl ester

2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[2-amino-1-(3-chloro-phenyl)-ethylcarbamoyl]-2-chloro-phenyl}-amide

(2-(3-chloro-phenyl)-2-{6-[8-(2-morpholin-4-yl-ethylamino)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-ylamino}-ethyl)-carbamic acid tert-butyl ester

(2-(3-chloro-phenyl)-2-{4-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-ethyl)-carbamic acid tert-butyl ester

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