cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

Base Information

Chemical Name:cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate
CAS No.:1185570-82-4
Molecular Formula:C₂₉H₂₉F₂N₃O₅
Molecular Weight:537.563
Hs Code.:

Synonyms:cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

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Chemical Property of cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

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Technology Process of cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

There total 10 articles about cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: cyclopentyl 2-amino-2-methylpropanoate hydrochloride

: 1185571-34-9
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

: 1185570-82-4
cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1185571-27-0
benzyl {4-[(tert-butoxycarbonyl)amino]phenyl}acetate

: 1185570-82-4
cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: acetic acid / 1 h / 80 °C

2.2: 0.5 h / 20 °C

3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 20 - 80 °C / Inert atmosphere

4.1: hydrogen / palladium on activated charcoal / ethyl acetate / 2 h / 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 3054-11-3
benzyl 4-aminophenylacetate

: 1185570-82-4
cyclopentyl N-({4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetyl)-2-methylalaninate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / 80 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 20 - 80 °C / Inert atmosphere

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 2 h / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;