{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

Base Information

Chemical Name:{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid
CAS No.:1185571-34-9
Molecular Formula:C₂₀H₁₄F₂N₂O₄
Molecular Weight:384.339
Hs Code.:

Synonyms:{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

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Chemical Property of {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

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Technology Process of {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

There total 7 articles about {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1185571-33-8
benzyl-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetate

: 1185571-34-9
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 3054-11-3
benzyl 4-aminophenylacetate

: 1185571-34-9
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / 80 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 20 - 80 °C / Inert atmosphere

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 2 h / 20 °C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid; ethyl acetate;

Reference yield:

: 1185571-31-6
benzyl (4-{[(1E)-1-amino-3-(2,4-difluorophenyl)-3-oxoprop-1-en-1-yl]amino}-phenyl)acetate

: 1185571-34-9
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 2 h / 20 °C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;