3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Base Information

Chemical Name:3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide
CAS No.:1053173-70-8
Molecular Formula:C₂₃H₁₉FN₂O₄
Molecular Weight:406.413
Hs Code.:

Synonyms:3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

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Chemical Property of 3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Chemical Property:

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Technology Process of 3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

There total 6 articles about 3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1053173-93-5
4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

: 1053173-70-8
3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Guidance literature:: With cyclohexene; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 1.5h; Heating / reflux;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1053173-70-8
3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 5 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: sodium hypobromide / 1,4-dioxane; water / 1 h / 0 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

5: cyclohexene / palladium 10% on activated carbon / ethanol; ethyl acetate / 1.5 h / Heating / reflux

With sodium hypobromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; cyclohexene; palladium 10% on activated carbon; L-proline; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1053173-79-7
4-(4-benzyloxy-phenyl)-4-(4-fluoro-phenylamino)-3-hydroxybutan-2-one

: 1053173-70-8
3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / -78 - 20 °C

2: sodium hypobromide / 1,4-dioxane; water / 1 h / 0 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

4: cyclohexene / palladium 10% on activated carbon / ethanol; ethyl acetate / 1.5 h / Heating / reflux

With sodium hypobromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; cyclohexene; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;