4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Base Information

Chemical Name:4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide
CAS No.:1053173-93-5
Molecular Formula:C₃₀H₂₅FN₂O₄
Molecular Weight:496.538
Hs Code.:

Synonyms:4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

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Chemical Property of 4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

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Technology Process of 4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

There total 5 articles about 4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1011265-03-4
4R-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid

: 100-46-9
benzylamine

: 1053173-93-5
4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1053173-93-5
4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: sodium hypobromide / 1,4-dioxane; water / 1 h / 0 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With sodium hypobromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1053173-93-5
4R-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: sodium hypobromide / 1,4-dioxane; water / 1 h / 0 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With sodium hypobromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;