2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

Base Information

Chemical Name:2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide
CAS No.:1444502-89-9
Molecular Formula:C₁₆H₂₆ClNO₃Si
Molecular Weight:343.926
Hs Code.:

Synonyms:2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

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Chemical Property of 2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

Chemical Property:

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Technology Process of 2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

There total 3 articles about 2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1353949-47-9
2-(2-chlorophenyl)-(R)-2-hydroxy-N-methoxy-N-methylacetamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1444502-89-9
2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 ℃;

Reference yield:

: 10421-85-9,52923-23-6,52950-19-3,52950-18-2
(R)-2-chloromandelic acid

: 1444502-89-9
2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 6 h / 20 °C

2.1: trimethylaluminum / hexane; dichloromethane / 2 h / 0 - 20 °C

2.2: 12 h / 20 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 0 °C

With 1H-imidazole; trimethylaluminum; trichlorophosphate; In hexane; dichloromethane;

Reference yield:

: 32345-59-8
methyl (R)-2-chloromandelate

: 1444502-89-9
2-(2-chlorophenyl)-N-methoxy-(R)-2-(t-butyl dimethylsiloxy)-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / hexane; dichloromethane / 2 h / 0 - 20 °C

1.2: 12 h / 20 °C / Reflux

2.1: 1H-imidazole / dichloromethane / 0 °C

With 1H-imidazole; trimethylaluminum; In hexane; dichloromethane;