N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Base Information

Chemical Name:N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester
CAS No.:247133-56-8
Molecular Formula:C₃₁H₄₀N₄O₇
Molecular Weight:580.681
Hs Code.:

Synonyms:N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Suppliers and Price of N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

There total 9 articles about N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939-80-0
4-chloro-3-nitrobenzonitrile

: 247133-56-8
N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / ethanol / 18 h / 20 - 50 °C

2: H₂ / Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

3: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

: 6456-74-2
Glycine tert-butyl ester

: 247133-56-8
N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / ethanol / 18 h / 20 - 50 °C

2: H₂ / Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

3: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

: 142717-44-0
Ethyl 2-(4-benzyloxyphenoxy)ethanoate

: 247133-56-8
N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / tetrahydrofuran / 7 h / 20 °C / 2280 Torr

2: DEAD; PPh₃ / tetrahydrofuran / 5 h / 20 °C

3: NaOH / tetrahydrofuran; ethanol / 0.5 h / 20 °C

4: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

With sodium hydroxide; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/j.bmcl.2004.06.009