5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

Base Information

Chemical Name:5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid
CAS No.:247133-57-9
Molecular Formula:C₂₇H₃₀N₄O₆
Molecular Weight:506.558
Hs Code.:

Synonyms:5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

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Chemical Property of 5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

Chemical Property:

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Technology Process of 5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

There total 10 articles about 5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247133-56-8
N-[4-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxyacetamido]-phenyl]glycine tert-Butyl Ester

: N-[4-cyano-2-[4-(piperidin-4-yloxy)phenoxyacetamido]phenyl]glycine

: 247133-57-9
5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

Guidance literature:: With trifluoroacetic acid; In acetic acid;

Reference yield:

: 939-80-0
4-chloro-3-nitrobenzonitrile

: 247133-57-9
5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / ethanol / 18 h / 20 - 50 °C

2: H₂ / Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

3: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

4: AcOH / 12 h / 75 °C

5: aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

With hydrogen; sodium carbonate; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

: 142717-44-0
Ethyl 2-(4-benzyloxyphenoxy)ethanoate

: 247133-57-9
5-Cyano-2-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenoxymethyl]-benzimidazole-1-acetic Acid

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / tetrahydrofuran / 7 h / 20 °C / 2280 Torr

2: DEAD; PPh₃ / tetrahydrofuran / 5 h / 20 °C

3: NaOH / tetrahydrofuran; ethanol / 0.5 h / 20 °C

4: 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CHCl₃ / 3 h / 20 °C

5: AcOH / 12 h / 75 °C

6: aq. Na₂CO₃ / tetrahydrofuran / 12 h / 20 °C

With sodium hydroxide; hydrogen; sodium carbonate; acetic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1016/j.bmcl.2004.06.009