5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))
CAS No.:225515-02-6
Molecular Formula:C₃₈H₄₄N₃O₈PS
Molecular Weight:733.822
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane)) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143526-94-7,139063-29-9
3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine

: 198637-74-0
2-chloro-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane

: 225515-02-6
5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

Guidance literature:: With tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; Yield given; Multistep reaction; 1.) MeCN, room temperature, 2 h, 2.) C₆H₆, room temperature, 1 h;
DOI:10.1021/jo982240r

Reference yield: 85.0%

: 21090-30-2
3'-O-acetylthymidine

: 225515-02-6
5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

: 5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyltrymidyl-(N3'->P5)-phosphoramidate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.5h;
DOI:10.1021/jo982240r

Reference yield:

: 225515-02-6
5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-(2-oxo-4-spiro(pentamethylene-1,3,2-oxophospholane))

: 1053631-67-6
5'-O-(4,4'-dimethoxytrityl)-2',3'-dideoxythymidine-3'-N-phosphoramidofluoridate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); In acetonitrile; for 1h;
DOI:10.1021/jo982240r