21090-30-2

Basic information

• Product Name: 3'-ACETYLTHYMIDINE
• Synonyms: 3'-ACETYLTHYMIDINE;3'-O-ACETYLTHYMIDINE;Thymidine 3'-acetate;3'-acetatethyMidine;3'-O-acetyl-2'-deoxythyMidine;(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate(WX160421);3'-O-AcetatethyMidine
• CAS NO: 21090-30-2
• Molecular Formula: C₁₂H₁₆N₂O₆
• Molecular Weight: 284.27
• Mol File: 21090-30-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 174 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.42g/cm³
• Storage Temp.: Store at 0-5°C
• PKA: 9.55±0.10(Predicted)
• CAS DataBase Reference: 3'-ACETYLTHYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-ACETYLTHYMIDINE(21090-30-2)
• EPA Substance Registry System: 3'-ACETYLTHYMIDINE(21090-30-2)

Safety Data

• Hazardous Substances Data: 21090-30-2(Hazardous Substances Data)

Usage

General Description

3’-acetylthymidine is a chemical compound that is derived from thymidine, a nucleoside found in DNA. It is primarily used as a chemical intermediate in the synthesis of various pharmaceuticals. The acetyl group attached to the 3’ position of thymidine enhances its stability and solubility, making it easier to handle and use in biological and chemical processes. This chemical has potential applications in drug development, specifically in the production of antiviral medications and as a research tool in the study of DNA and RNA structure and function. Additionally, 3’-acetylthymidine may have potential therapeutic applications, given its relevance to nucleoside analogues and antiviral compounds. Overall, 3’-acetylthymidine is a valuable chemical with diverse potential applications in the field of pharmaceuticals and biotechnology.

Upstream product

• 108-24-7 acetic anhydride 
• 50-89-5 thymidine 
• 1352211-97-2 C₂₇H₃₀N₄O₈ 
• 1352211-98-3 C₂₇H₂₈F₂N₄O₈ 
• 1352211-82-5 2-((2,4-difluorobenzyl)(pyridin-2-yl)amino)ethanol 
• 1053653-67-0 3'-O-acetylthymidine 5'-O-(1-imidazolyl)carbamate 
• 872298-31-2 2-(N-benzyl-pyridin-2-yl-amino)ethanol 
• 6979-97-1 3',5'-diacetylthymidine 
• 23583-46-2 3'-O-acetyl-5'-O-triphenylmethylthymidine 
• 100-51-6 benzyl alcohol 
• 56070-42-9 (2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate 
• 648900-05-4 Acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[2-(pyridin-2-ylamino)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester 

Downstream Products

• 63914-07-8 3'-O-toluoyl-β-thymidine 
• 365-07-1 thymidine 5'-phosphate 
• 79284-80-3 C₅₇H₆₁N₄O₁₄PSi 
• 77086-90-9 3'-O-acetyl-5'-O-1,3,2-oxazaphosphacyclohex-2-ylthymidine 2-oxide 
• 172945-90-3 3'-O-acetylthymidine-5'-O-(S-trityl-3-thiopropyl)methoxyphosphite 
• 172945-89-0 3'-O-acetylthymidine-5'-O-(S-trityl-3-thiopropyl)(2-cyanoethyl)phosphite 
• 90814-42-9 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate 
• 71790-91-5 (MeO)2TrdbzAp(Me)T(Ac) 
• 90865-75-1 (R_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate 
• 90865-76-2 (S_P)-5'-O-DMT-thymidylyl-(3',5')-3'-O-acetylthymidine 3'-methanephosphonate 
• 252931-78-5 5'-O-DMT thymidylyl 3'-O-acetylthymidine (3',5')-methanephosphonothioate 
• 4829-64-5 2'-deoxycytidylyl-(3',5')-thymidine phosphate 
• 189153-41-1 C₄₉H₅₂N₅O₁₄PS 
• 23339-47-1 d(ApT) 

Relevant articles and documents

Modulating the Stability of 2-Pyridinyl Thermolabile Hydroxyl Protecting Groups via the "chemical Switch" Approach

A novel and effective method is presented for modulating the stability of 2-Pyridinyl Thermolabile Protecting Groups (2-Py TPGs) in the "chemical switch" approach. The main advantage of the discussed approach is the possibility of changing the nucleophili

Semisynthetic peptide-lipase conjugates for improved biotransformations

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID

Provided herein are methods and compositions for nucleic acid amplification. These methods involve the use of 3'-substituted nucleoside 5'-triphosphates or 3'-substituted terminated primers in nucleic acid amplification reactions. In certain aspects, the methods are accomplished by use of 3'-substituted NTPs and/or 3'-substituted terminated primers which provide utility in nucleic acid amplification. In preferred embodiments, the NTPs and/or primers are substituted at the 3'-position with particular heat labile chemical groups such as ethers, esters or carbonate esters.