2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

Base Information

Chemical Name:2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile
CAS No.:1189135-39-4
Molecular Formula:C₂₀H₁₇ClFN₃
Molecular Weight:353.826
Hs Code.:

Synonyms:2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

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Chemical Property of 2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

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Technology Process of 2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

There total 4 articles about 2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1189135-15-6
2-chloro-4-{4-[(E)-2-(4-fluorophenyl)ethenyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

: 1189135-39-4
2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.02.005

Reference yield:

: 1189140-58-6
2-chloro-4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)benzonitrile

: 1189135-39-4
2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.5 h / 120 - 130 °C / Microwave irradiation

2: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C

With 5%-palladium/activated carbon; tetrabutyl-ammonium chloride; hydrogen; palladium diacetate; sodium hydrogencarbonate; In ethyl acetate; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/j.bmc.2012.02.005

Reference yield:

: 154606-56-1
2-chloro-4-(3,5-dimethyl-1H-pyrazol-1-yl)benzonitrile

: 1189135-39-4
2-chloro-4-{4-[2-(4-fluorophenyl)ethyl]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetonitrile / 144 h / 20 °C

2: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.5 h / 120 - 130 °C / Microwave irradiation

3: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 3 h / 20 °C

With N-iodo-succinimide; 5%-palladium/activated carbon; tetrabutyl-ammonium chloride; hydrogen; palladium diacetate; sodium hydrogencarbonate; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 2: Heck reaction;
DOI:10.1016/j.bmc.2012.02.005