4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

Base Information

Chemical Name:4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine
CAS No.:1418112-79-4
Molecular Formula:C₁₈H₂₀ClFN₂O₃S
Molecular Weight:398.886
Hs Code.:

Synonyms:4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

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Chemical Property of 4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

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Technology Process of 4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

There total 10 articles about 4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165524-52-7
(R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethan-1-ol

: 1418112-78-3
4,6-dichloro-2-(4-fluorobenzylthio)pyrimidine

: 1418112-79-4
4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil; at 0 - 20 ℃; for 20.3333h;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1418112-79-4
4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / acetonitrile; water / 22 h / 20 °C

2: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux

3: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium acetate; sodium hydride; trichlorophosphate; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,2-dimethoxyethane; water; acetonitrile; mineral oil;

Reference yield:

: 401581-40-6
2-(4-fluorobenzylthio)pyrimidine-4,6-diol

: 1418112-79-4
4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux

2: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; trichlorophosphate; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,2-dimethoxyethane; mineral oil;