Technology Process of 4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine
There total 10 articles about 4-chloro-6-((R)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethoxy)-2-(4-fluorobenzylthio)pyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 20.3333h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium acetate / acetonitrile; water / 22 h / 20 °C
2: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux
3: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C
With
N-benzyl-N,N,N-triethylammonium chloride; sodium acetate; sodium hydride; trichlorophosphate;
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,2-dimethoxyethane; water; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 1,2-dimethoxyethane / 10 h / Reflux
2: sodium hydride / tetrahydrofuran; 2-methyltetrahydrofuran; mineral oil / 20.33 h / 0 - 20 °C
With
N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; trichlorophosphate;
In
tetrahydrofuran; 2-methyltetrahydrofuran; 1,2-dimethoxyethane; mineral oil;
